EntreMed commences ENMD-2076 Phase 2 study in triple-negative breast cancer

EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company, announced today the initiation of a dual-institutional Phase 2 study of ENMD-2076 in triple-negative breast cancer. Jennifer R. Diamond, MD at the University of Colorado serves as the principal investigator for the study. The study is sponsored by EntreMed and is supported by a grant from the National Cancer Institute. 

Jennifer R. Diamond, MD, stated, "Triple-negative breast cancer represents an aggressive breast cancer subtype which carries a high risk of developing distant metastasis.  It remains an area of unmet need in terms of effective anti-cancer agents with innovative patient selection strategies. We are encouraged by the data from the Phase 1 study of ENMD-2076 in patients with advanced solid tumors, including triple-negative breast cancer. ENMD-2076 has also demonstrated significant anti-tumor activity against preclinical models of breast cancer with more robust activity against triple-negative breast cancer alone or in combination with standard chemotherapies.  This single-agent Phase 2 study is designed to determine the activity of ENMD-2076 by the clinical benefit rate in patients with previously treated locally advanced or metastatic triple-negative breast cancer."

Ken Ren, Ph.D., EntreMed's Chief Executive Officer commented, "The development of ENMD-2076 to address the unmet medical need for an effective treatment of triple-negative breast cancer represents a part of our integrated initiatives in the clinical advancement of the ENMD-2076 oncology platform. ENMD-2076 is unique in its class and has demonstrated promising clinical activity across multiple oncology indications in our previous clinical trials. To maximize the value proposition of ENMD-2076, we are evaluating several of those indications as possible targets for further clinical trials while leveraging resources in both the US and China. Additionally, following the Phase 1 and Phase 2 results of ENMD-2076 in ovarian cancer, we are evaluating the next trial in this indication.  We will continue to execute on our clinical development plans this year and appreciate the support and encouragement of Dr. Diamond and our other investigators and clinical advisors. We are grateful not only to their collective expertise in specific oncology areas but also to their passion, commitment and contributions to bring ENMD-2076 to patients."