Data from IMUC’s ICT-107 Phase I trial on glioblastoma multiforme accepted for publication

Published on August 9, 2012 at 4:20 AM · No Comments

ImmunoCellular Therapeutics (NYSE MKT: IMUC) announced today that clinical data from its Phase I trial of ICT-107 was accepted for publication, and is currently in the online edition of the prestigious medical journal Cancer Immunology, Immunotherapy (http://www.springerlink.com/content/n0018574g9m4v587/fulltext.pdf). In the publication, the data showed that the expression of four ICT-107 targeted antigens in the pre-vaccine tumors correlated with longer overall survival (OS) and progression free survival (PFS) in newly diagnosed glioblastoma multiforme (GBM) patients. Median PFS in newly diagnosed GBM patients was 16.9 months and median OS was 38.4 months.    

Tumors from post-vaccine resections in five patients showed a decrease in or loss of the cancer stem cell associated antigen CD133 relative to their pre-vaccine counterparts, which may be promising because previous studies have consistently shown increased expression of CD133 in recurrent tumors. The idea of cancer stem cell therapeutics has received increasing attention, including through publications noting IMUC's progress in the clinic with its ICT-107 vaccine targeting antigens associated with cancer stem cells and articles in the recent issues of Nature and Science noting the significance of cancer stem cells to tumor growth.

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