Published on August 13, 2012 at 10:32 AM
Professor Sally Lawson, Emeritus Professor from the University’s School of Physiology and Pharmacology who led the research at Bristol, said: “We hope that our findings will trigger further studies that will clarify how and why these nerve cells with uninjured fibres running through a damaged nerve change so remarkably and contribute to pathological pain, and determine how to reverse these changes.”
Dr Laiche Djouhri, the first author, now at Liverpool (Department of Molecular and Clinical Pharmacology), added: “This should help the understanding of how to target pathological pain more effectively, taking into account the different neuron types involved. This may in the longer term help development of more effective pain killers to help sufferers of neuropathic pain.”
The Wellcome Trust-funded research, entitled ‘Partial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: Possible relationships to aspects of peripheral neuropathic pain and paresthesias’ by Laiche Djouhri , Xin Fang, Stella Koutsikou, Sally N. Lawson from the School of Physiology and Pharmacology at the University of Bristol, is published in the September issue of the journal Pain.