Researchers at Moffitt Cancer Center and colleagues have published a study describing the greater difficulty in finding matched, unrelated donors for non-Caucasian patients who are candidates for hematopoietic cell transplantation (HCT).
The study appeared in the August issue of Bone Marrow Transplantation.
The success of HCT depends on finding cell donors who are closely matched genetically; as the degree of mismatching increases, the success of unrelated donor HCT falls accordingly. A patient's ideal donor is a genetically matched sibling.
The search for a perfectly matched donor for all groups takes time and affects the progression to transplantation. The National Marrow Donor Program estimates that the genetically matched donor rate is 90 percent for Caucasian patients, 70 percent for Hispanics and Asians, and 60 percent for those of African ancestry.
"Using unrelated adult donors to facilitate HCT has provided major opportunities for patients without a matched sibling donor. In fact, the rate of unrelated donors now exceeds the rate of related donor HCT," said Joseph Pidala, M.D., M.S., assistant member of Moffitt's Blood & Marrow Transplant Department and a member of the Immunology Program. "Using data available at Moffitt, we sought to describe the determinants of a successful, unrelated donor search and to explore the contribution of donor identification versus patient characteristics leading to successful transplantation outcome."
According to Pidala, many patients can achieve prolonged, condition-free survival after unrelated donor HCT. There is, however, a need to understand "modifiable factors" that limit access to unrelated donor HCT.
The researchers concluded that the difficulties in finding well-matched donors in some minority groups were likely related to the degree of genetic heterogeneity within those groups, as well as their underrepresentation in donor pools.