Mayo researchers discover new therapy for patients with neuromyelitis optica

Published on October 10, 2012 at 2:05 AM · 1 Comment

Mayo Clinic researchers have identified a new therapy for patients with neuromyelitis optica that appears to stop inflammation of the eye nerves and spinal cord. NMO is a debilitating central nervous system disorder that is often misdiagnosed as multiple sclerosis (MS). In the study, patients with severe symptoms of the disease, also known as NMO, were given eculizumab, a drug typically used to treat blood disorders.

While not a cure, the therapy Mayo Clinic researchers used in the study to halt attacks could potentially lead to longer attack-free periods for the thousands of NMO patients worldwide. The research is being presented Oct. 9 at the American Neurological Association Annual Meeting in Boston.

NMO manifests itself in attacks that can cause blindness in one or both eyes, weakness or paralysis in the legs or arms, painful spasms, loss of sensation, and bladder or bowel dysfunction from spinal cord damage. Attacks may be reversible, but can be severe enough to cause permanent visual loss and problems with walking. NMO can affect children as young as 2 and adults as old as 90. It is more prevalent in females than males, but affects all racial and ethnic groups. Immunosuppressants are the first line of treatment for NMO.

Mayo Clinic researchers have been international leaders in NMO diagnosis and treatment. In 2004, Mayo Clinic researchers discovered the antibody NMO-IgG -- the first serum biomarker for any form of inflammatory demyelinating brain disease. A year later, they identified the target of the antibody as the water channel aquaporin 4. These discoveries helped physicians better understand the cause and potential treatments for NMO.

Mayo researchers studied 14 NMO patients with active and severe disease symptoms, defined as two attacks in the previous six months, or three within the past year. When the NMO-IgG antibody binds to its target on brain cells, it activates complement, a substance that can kill or injure these brain cells. Patients were treated with eculizumab, an antibody that stops complement from being activated. All 14 study participants received the treatment intravenously every two weeks for one year.

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Comments
  1. Editha Thomson Editha Thomson Brunei Darussalam says:

    I'm so glad to find your website and give me inspiration after reading it was very helpful and  giving us a lot of information for possible treatment to all NMO patients. I am very thankful  for Mayo clinic for your non-stop doing the research for the treatment of this disease. I  had Devic disease which I got 3 attacks of optic neuritis and one attack on my spine and had been taking  azathioprine for almost a year now. Do you think taking therapy will get my life back to normal.?

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