Drug-eluting stents exhibit some benefits in patients over 80

Published on October 29, 2012 at 4:00 AM · No Comments

Rarely tested in patients over the age of 80, a study found that drug-eluting stents exhibited some benefits over bare-metal stents, though both types of stents demonstrated a clinical benefit. Results of the XIMA trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

Patients over the age of 80 are often excluded from randomized clinical trials, but this age group represents an increasing proportion of the daily revascularization workload, and in fact the fastest growing segment of the population. Octogenarians are more likely to present with complex coronary disease, anatomically expectant of drug- eluting stenting (DES). However, these same patients are at higher risk of bleeding complications from prolonged dual antiplatelet therapy (DAPT).

XIMA is an international, multicenter, prospective randomized trial to examine the safety and efficacy outcomes among octogenarians with either a bare-metal stent (BMS) or drug-eluting (DES) stent implantation for complex coronary disease in the context of stable angina or an acute coronary syndrome. Heart attack patients were excluded.

The trial enrolled 800 patients aged 80 or above who underwent angiography for stable angina or following an acute coronary syndrome. If the coronary narrowing was deemed suitable for stenting and the lesion was either ≥15mm long and/or ≤3mm diameter, the patient was randomized to receive either BMS or DES. As long as stent deployment was considered feasible, there were no anatomical exclusions to the trial, which could include chronic total occlusions, bifurcations, severe calcification and left main stem lesions.

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