PsiOxus receives UK government grant to initiate ColoAd1 Phase I/II trial for ovarian cancer

Published on November 5, 2012 at 6:47 AM · No Comments

PsiOxus Therapeutics, Ltd. (PsiOxus), a development stage biotechnology company, today announced the award of a £1.7 million ($2.7 million) grant from the UK government-backed Biomedical Catalyst to initiate a Phase I/II clinical trial to assess the use of ColoAd1 in the treatment of platinum-resistant, recurrent ovarian cancer. The OCTAVE (Ovarian Cancer Treated with AdenoVirus) study will be the second clinical trial of the systemically available oncolytic vaccine ColoAd1, which is a highly potent, broad-spectrum, anticancer therapeutic capable of destroying tumour cells at minute concentrations.

The OCTAVE Phase I/II study will assess the safety and efficacy of ColoAd1 when given to patients by intra-peritoneal perfusion at multiple UK cancer centres beginning in 2013. The Principal Investigator of the OCTAVE study will be Professor Iain McNeish from the Institute of Cancer Sciences at the University of Glasgow. Over 50 ovarian cancer patients will receive multiple doses of intra-peritoneal ColoAd1 in this clinical trial and will be assessed for immunological responses as well as tumor response and survival.

"Ovarian cancer is the fourth most common cause of cancer death for women in the UK," said Iain McNeish, Professor of Gynecological Oncology at the University of Glasgow Institute of Cancer Sciences. "This funding for the OCTAVE study will enable us to evaluate in great detail the use of ColoAd1 as a very exciting potential new treatment for ovarian cancer."

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