People more likely to take heart medicines in combo pill

Published on November 7, 2012 at 7:12 AM · No Comments

People are much more likely to take heart medicines if they're combined in one pill, according to a late-breaking clinical trial presented at the American Heart Association's Scientific Sessions 2012.

"This is the first time the impact of a fixed-dose, combination strategy has been tested in people with cardiovascular disease," said Simon Thom, M.D., F.R.C.P., lead author of the study and professor of cardiovascular medicine and pharmacology at Imperial College London, U.K.

"People who have suffered heart attacks or strokes or those at high risk of such problems need to take preventive medications, including antiplatelet drugs (such as aspirin), cholesterol-lowering and blood pressure-lowering drugs. But the reality is that large numbers of people in this high-risk category get out of the habit of taking the recommended medications," Thom said. "This happens for a variety of reasons; some of which may be corrected by a single, simple, fixed dose combination pill - a combination known as a 'polypill.'"

There has been uncertainty about a fixed dose combination strategy for cardiovascular disease prevention. While many physicians have anticipated that adherence might be improved, reduced flexibility in adjusting dosages and numbers of individual agents could have offset the benefits of simplicity.

Alice Stanton, lead Irish Investigator, Co-author and Professor of Molecular and Cellular Therapeutics at RCSI, Dublin, commented. "This trial showed improvements in adherence being paralleled by improvements in blood pressure and cholesterol, despite the control group in the trial being treated much better than average."

Typically, in high-income countries such as the United States only about 50 percent of people take all the needed cardiovascular medications. In low- and middle-income countries, only 5 percent to 20 percent do.

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