Tiltan Pharma Ltd. today announced that it has enrolled the first U.S. patient, at White Plains Hospital in Westchester County N.Y., in a Phase 2 clinical trial of its anti-angiogenic product, TL-118, for the treatment of metastatic pancreatic cancer.
The Phase 2 study is already ongoing in four major oncology centers in Israel: The Tel Aviv Sourasky Medical Center, Hadassah Medical Center, Assaf HaRofeh Medical Center and the Rambam Medical Center. The clinical trial will enroll 80 patients with newly diagnosed metastatic pancreatic cancer that have not yet been treated with chemotherapy. The trial includes two treatment groups with 40 subjects each. The control group is allocated to standard chemotherapy for pancreatic cancer, and the treatment group receives TL-118 in addition to standard-of-care chemotherapy.
Dr. Dan Costin, Director Westchester Institute for Treatment of Cancer and Blood Disorders, Co-Medical Director of White Plains Hospital Cancer Program and Principal Investigator for the TL-118 Study at White Plains Hospital, said: "We are happy to introduce this cutting edge therapy to our pancreatic cancer patients. Unfortunately, metastatic pancreatic cancer is a disease with very poor prognosis and we are urgently seeking new solutions that might enhance survival. Dr. Costin added, "TL-118, which belongs to the family of angiogenesis inhibiting drugs demonstrated outstanding efficacy in pre-clinical studies, a promise we hope will be translated into significant clinical benefit to people suffering from pancreatic cancer."
Dr. Dan Goldstaub, Tiltan's Chief Operating Officer, said, "We are very pleased with the addition of the U.S. site to our study. The trial is advancing as planned, and we are satisfied with the recruitment rate. In Israel 15 patients were already enrolled, and we are certain that the new U.S. site will expedite the clinical trial. We are closely monitoring the efficacy, safety and tolerability of the product and so far we are happy with the outcome."