"'Getting to Zero' has been the slogan for World AIDS Day (Dec. 1) since 2011 and will remain so through until 2015, coinciding with the Millennium Development Goal target of halting and beginning to reverse the spread of HIV/AIDS," Francoise Barre-Sinoussi, director of the Regulation of Retroviral Infections Unit at the Institut Pasteur in Paris, and Adeeba Kamarulzaman, director of the Center of Excellence for Research in AIDS and dean of the Faculty of Medicine at University of Malaya in Kuala Lumpur, write in a New York Times opinion piece. "This offers a starting point for some more sanguine reflection on how, amid generalized talk of zeros, targets and goals, we can so easily lose sight of the extraordinary barriers that prevent them being reached in the first place," they continue.