Amarantus demonstrates excellent diffusion profile of MANF in the striatum of rat brains

Published on November 27, 2012 at 8:47 AM · No Comments

Amarantus BioSciences, Inc. (OTCQB: AMBS), a biotechnology company developing new disease-modifying treatments and diagnostics for Parkinson's disease and Traumatic Brain Injury centered on its proprietary anti-apoptosis therapeutic protein MANF, today announced that the Company has successfully completed experiments demonstrating that MANF has an excellent diffusion profile in the striatum of rat brains. The striatum is located in the brain, and is partially responsible for proper movement as part of the basal ganglia network. The striatum becomes severely compromised in Parkinson's disease due to neurite retraction from dopaminergic neurons located in the substantia nigra. The data generated in this study show that when compared to GDNF, a neurotrophic factor currently in a Phase 2 clinical trial for Parkinson's disease, MANF had a significantly higher volume of distribution when delivered to the striatum. These results are part of on-going animal studies to determine the best localization of delivering MANF to the brain in Parkinson's disease human clinical studies. 

"The data obtained in this study provide strong evidence that volume distribution from the site of delivery in the brain is unlikely to be an impediment to MANF's clinical progress," said John W. Commissiong, PhD, Chief Scientist at Amarantus. "Volume distribution from the site of delivery appears to have been one of the key shortfalls of previous clinical trials of neurotrophic factors in Parkinson's disease.  These results provide a higher degree of certainty that MANF is unlikely to fail in the clinic due to inadequate diffusion volumes."

In studies conducted by Dr. Steven Gill's laboratory at the University of Bristol, MANF and GDNF were injected directly into the striatum of separate groups of rats in order to mimic as closely as possible the treatment setting in humans. Seven days following delivery under best available conditions, MANF's diffusion volume was ~30% greater than GDNF's.

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