Good news may be on the horizon for Kate Middleton, Duchess of Cambridge, and other women stricken with severe nausea and vomiting during pregnancy, thanks to the work of a University at Buffalo professor who is conducting research on a drug that is showing success treating pregnant women with this condition.
Thomas Guttuso Jr., MD, assistant professor of neurology in the UB School of Medicine and Biomedical Sciences, has been studying the drug gabapentin, an anti-seizure and anti-pain drug that he previously had studied in cancer patients receiving chemotherapy.
A photo of Guttuso is at http://www.buffalo.edu/news/13847.
"I became interested in this drug for hyperemesis gravidarum (an extreme form of morning sickness) because I saw how effective it appeared to be in treating chemotherapy-induced nausea and vomiting in patients who had failed treatment with conventional anti-emetics," says Guttuso. Anti-emetics are drugs currently approved for treating nausea and vomiting.
In 2010, he published in the journal Early Human Development the results of an open-label pilot study that enrolled seven women from Western New York examining the drug's safety, tolerability and effectiveness in treating hyperemesis gravidarum.
"It was really exciting to see how quickly the women responded," says Guttuso.
None of the women had seen any improvement on any other anti-emetic medications they had tried.
"But when they started with gabapentin, all of them showed a dramatic improvement," he says. "Within two hours of taking the first pill, most of the patients were feeling much better and several were able to start eating and drinking again. It was a pretty amazing thing to see.
"The study showed that after two weeks of gabapentin therapy, the seven women experienced an average 80 percent reduction in their nausea and a 94 percent reduction in their vomiting and near normal levels of eating and drinking," Guttuso says. After this study was published, Guttuso knows of five more women with hyperemesis gravidarum that tried gabapentin and all experienced excellent relief.
The women needed to take gabapentin on average until about half way through their pregnancies before they could stop it without recurrent nausea and vomiting.
One of the potential concerns with gabapentin was that two of the babies born to patients in the UB study were found to have congenital defects. As a result, the Food and Drug Administration placed the study on clinical hold in April 2011 until further safety data was available on the use of gabapentin during pregnancy.
By May 2012 several pregnancy registries and other studies had reported that the rate of congenital defects among a total of 258 infants born to women taking gabapentin early in their pregnancies was about the same as the rate of congenital defects in the general population. After reviewing these findings, the FDA removed the clinical hold allowing Guttuso to resume his research on the effects of gabapentin on hyperemesis gravidarum.
Although the results of the small pilot study were very encouraging, Guttuso emphasizes that a placebo-controlled study among many more patients needs to be conducted in order to know if gabapentin truly is effective for hyperemesis gravidarum. "The evidence right now is still very preliminary," he states.
Early next year, Guttuso plans to submit a new grant proposal to the National Institutes of Health in order to support such a study with enrolling sites both at UB and at the University of Rochester. Guttuso is hopeful that the study will be funded.
"This is a study that really needs to be done because currently there are no effective treatments for hyperemesis gravidarum," Guttuso says. "Women end up having to keep going back to the hospital for intravenous fluids because of dehydration from their persistent nausea and vomiting."