Critically ill patients in hospital intensive care units (ICUs) are routinely prescribed acid-suppressive medications to reduce their risk of developing stress ulcers and gastrointestinal bleeding, both of which can result from being in a stressful environment and from being intubated. Over the years, this routine practice has often been extended to patients outside the ICU, despite a lack of evidence that this population is at significant risk of these complications.
Now a study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) describes a new scoring system to help clinicians better identify non-ICU hospital patients who are at risk for GI bleeding. Appearing in the Journal of General Internal Medicine, the new findings could help doctors to selectively use acid-suppressive medications when needed - and avoid using them when there is no indication that patients are at risk - thereby saving costs and avoiding the medications' sometimes serious side effects.
"Current guidelines recommend against the routine use of acid-suppressive medication to prevent stress ulcers in non-ICU patients. Moreover, there is growing evidence that these drugs are associated with an increased risk of complications, including hospital-acquired pneumonia and clostridium difficile," explains first author Shoshana Herzig, MD, an investigator in BIDMC's Division of General Medicine and Primary Care and Instructor in Medicine at Harvard Medical School. "Despite these factors, acid-suppressive medications continue to be used indiscriminately in non-ICU patients."
However, she adds, eliminating their use altogether is not the answer. "It would be preferable to target use of these medications to patients who need them most. We had observed that there was a lack of evidence to guide physicians in prescribing acid-suppressive medications for stress ulcer prophylaxis in patients outside the ICU. Our goal was to provide data that might help clinicians to more appropriately prescribe these medications."
The authors examined records of 75,723 patient admissions at Beth Israel Deaconess Medical Center over a four-year period. Patients were excluded if they had been admitted to the hospital with an existing case of GI bleeding, if they developed a bleed within a day of admission or if they were scheduled to undergo cardiac catheterization, which exposes them to high levels of medications that impair clotting.