Bone Medical Ltd (ASX: BNE), a biopharmaceutical company focused on the development of new medicines for musculoskeletal diseases, today announced initial findings from a proof of concept study of BN006, a treatment that it is developing for Rheumatoid Arthritis (RA) based on its Mozaic™ peptide discovery technology.
These first results confirm that BN006 reduces inflammation in a collagen-antibody induced arthritis disease model, a widely used benchmark for evaluating and comparing novel treatments for RA. The reduction appeared to be dose-related.
Significantly, BN006 achieved notable reduction in inflammation with only a modest reduction of TNF. TNF is one of the body's inflammatory agents that play an important role in the RA disease process. BN006 has also been shown to reduce IL-6, another cytokine involved in RA.
Dr Roger New , CSO and inventor of the Mozaic™ system, explained, "The current standard of care for the treatment of RA works by binding to TNF and blocking its activity systemically. This approach reduces TNF's ability to play its role in the body's immune response, leading to the adverse events that most commonly limit the clinical role of these products."