As the first countries in the world, Norway and France will be testing a completely new method for detecting cancer. This is done by measuring the elasticity of tumours. The method is called elastography. You may as well learn this new word right away; in a few years, elastography may be as common as X-rays.
"Elastography gives oncologists yet another method for detecting tumours. Elastography may be especially suitable for determining how serious the illness is," says radiologist and clinical consultant Per Kristian Hol at the Intervention Centre at Oslo University Hospital, Rikshospitalet.
To detect cancer, determine how the cancer is developing and how dangerous it is, hospitals must often use large and expensive methods such as X-rays, MR, CT or PET.
"Some of the methods use a lot of radiation. Others are very expensive to run."
Every year, nearly one hundred Norwegians get cancer from X-rays. This is what radiologist Lars Borgen found in his dissertation in clinical medicine last year. The radiation from a round in a CT machine is ten times higher than the average background radiation during an entire year, according to particle physicist Erlend Bolle. For PET scans, the patient is injected with radioactive tracers.
"We want the best possible diagnostics with the least possible radiation. Elastography is completely safe.", says Hol.
A promising method
Elastography can be combined with either MR or ultrasound. MR machines are expensive.
"Ultrasound is cheap, but the result depends a lot on how good the ultrasound examination is. In the future, we envision that elastography will be performed at a regular doctor's office", says Hol.
The University Hospital is now planning to test the method on patients.
"We still don't know a lot about elastography, but the method looks promising. If elastography is the technique we are hoping for, this can become an important examination in the future. This would allow us to use elastography to characterize different types of tumours, such as cancer of the liver", says Anne Cathrine T. Martinsen, who is the Section Manager of diagnostic physics at the Intervention Centre and Associate Professor in the Department of Physics at the University of Oslo.
Tumours do not have the same elasticity as healthy tissue. Elasticity is related to the density of blood vessels. Tumours have more blood vessels than healthy tissue. Malignant tumours usually have even more blood vessels and a greater blood flow than benign tumours.
"Different tumours at different stages of the development of the cancer have different elasticity. Tumours may be less or more elastic than healthy tissue. Some tumours may spread, while others do not. In other words, we can get an entirely new map of organs and tumours by measuring elasticity."
The examination is simple. The doctor places a vibrator on the location that is to be examined. The vibrator has a pulse of up to 200 oscillations per second. The pressure wave from the vibrator goes through the organ. This allows doctors to study the elasticity of the healthy and diseased parts.
Researchers at the Hôpital Beaujon university hospital in Paris are already testing elastography on patients with liver fibrosis, an illness in which the liver has become stiff due to hepatitis or alcohol damage.
The Intervention Centre in Oslo is now planning to test the method on Norwegian patients with liver fibrosis. The method can replace biopsy. This means that patients do not have to have a needle inserted into their liver.
The trick: divide the waves!
In the last four years, Professor Sverre Holm in the Department of Informatics at the University of Oslo, Norway, has collaborated closely with the French researchers. Holm has researched ultrasound for 20 years and is also Adjunct Professor in the Department of Circulation and Medical Imaging at the Norwegian University of Science and Technology.
"Elastography-ultrasound is completely different from the current use of ultrasound. Traditional ultrasound sends out a signal that returns as an echo. The problem is that it is impossible to distinguish between malignant and benign tumours with regular ultrasound", says Holm to the research magazine Apollon.
And this is where Apollon gets to the point: Ultrasound creates two types of waves. The most common type is pressure waves. Pressure waves go down into the tissue. The other waves are created by the radiation pressure from pressure waves and run horizontally. These waves are called shear waves.
While pressure waves are mostly affected by fluids, the shear waves capture the characteristics of the other 30 per cent of the body that does not consist of water.
Until today, it has not been possible to measure shear waves.