Highlights for Feb. 2013 issue of Genetics journal

Published on February 10, 2013 at 11:28 AM · No Comments

Listed below are the selected highlights for the February 2013 issue of the Genetics Society of America's journal, Genetics. The February issue is available online at www.genetics.org/content/current. Please credit Genetics, Vol. 193, February 2013, Copyright - 2013.

Please feel free to forward to colleagues who may be interested in these articles on population and evolutionary genetics; gene expression; genome and systems biology; and methods, technology and resources.

ISSUE HIGHLIGHTS

Population and Evolutionary Genetics
Patterns of transcriptome divergence in the male accessory gland of two closely related species of field crickets, pp. 501-513
Jose A. Andr-s, Erica L. Larson, Steven M. Bogdanowicz, and Richard G. Harrison

What kinds of genetic changes are responsible for the origin of species? What forces drive evolution of "speciation genes"? Answers to these fundamental questions may be found by examining patterns of genomic differentiation between closely related species. The authors have compared transcriptomes of two field crickets to identify candidate gene regions that contribute to reproductive isolation and to assess the role of selection in divergence of genes encoding seminal fluid proteins.

Methods, Technology and Resources Captured segment exchange: A strategy for custom engineering large genomic regions in Drosophila melanogaster, pp. 421-430
Jack R. Bateman, Michael F. Palopoli, Sarah T. Dale, Jennifer E. Stauffer, Anita L. Shah, Justine E. Johnson, Conor W. Walsh, Hanna Flaten ,and Christine M. Parsons and
Long-range targeted manipulation of the Drosophila genome by site-specific integration and recombinational resolution, pp. 411-419
Natalia Wesolowska and Yikang S. Rong

This issue of Genetics features two articles that describe significant improvements in the Drosophila genetic toolbox (see Commentary by Crown and Sekelsky). Wesolowska and Rong describe an approach for targeted manipulation of the genome that promises to render all Drosophila genes amenable to systematic targeted mutagenesis. Bateman et al. offer a novel approach for swapping large segments of the genome with engineered DNA, permitting custom alterations to any genomic region. And last month Staller and Perrimon and colleagues presented a powerful, simple method for depleting gene function in early embryos with short hairpin RNAs.

Population and Evolutionary Genetics
Evolutionary rate covariation in meiotic proteins results from fluctuating evolutionary pressure in yeasts and mammals, pp. 529-538
Nathan L. Clark, Eric Alani, and Charles F. Aquadro

Genes leave records of their relationships in their DNA: functionally related genes tend to experience parallel changes in evolutionary rate. What causes this coevolutionary signature? These authors suggest that such a signature in meiotic genes results from a reduction in selective constraint after certain species switched to clonal reproduction. Similar changes in coevolutionary signatures across the genome can be exploited to uncover functional relationships.

Population and Evolutionary Genetics
The effect of nonindependent mate pairing on the effective population size, pp. 545-556
Ben J. Evans and Brian Charlesworth

This study illuminates how real-world social systems impinge on genome evolution. The effect of overlapping generations on effective population size is generally inferred by assuming that mate pairing occurs independently each breeding season-an assumption violated by many species, including humans. Evans and Charlesworth show that nonindependent mate pairing has no effect if all adults mate pair each breeding season, a small effect if females store sperm, and a large effect with a harem social system.

Population and Evolutionary Genetics
The relationship between FST and the frequency of the most frequent allele, pp. 515-528
Mattias Jakobsson, Michael D. Edge, and Noah A. Rosenberg

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