Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

Published on February 28, 2013 at 11:23 AM · 2 Comments

For the first time, scientists have discovered that five major psychiatric disorders—autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder and schizophrenia—share several common genetic risk factors.  In particular, variations in two genes involved in the balance of calcium in brain cells are implicated in several of these disorders and could be a target for new treatments. The findings from the largest ever genetic study of psychiatric illness, published Online First in The Lancet, may help to one day reclassify these disorders on the basis of causes rather than descriptive syndromes.

“This analysis provides the first genome-wide evidence that individual and aggregate molecular genetic risk factors are shared between five childhood-onset or adult-onset psychiatric disorders that are treated as distinct categories in clinical practice”, explains Jordan Smoller from Massachusetts General Hospital in Boston, one of the lead researchers.

To examine the possibility of common genetic markers or nucleotide polymorphisms (SNPs) that might affect susceptibility to the five disorders, the Psychiatric Genomics Consortium (PGC) scanned the genome of 33 332 patients and 27 888 controls of European ancestry.

They identified four risk loci that have significant and overlapping links with all five diseases—regions on chromosomes 3p21 and 10q24, and SNPs in two genes that make components of channels that regulate the flow of calcium in brain cells (CACNA1C; linked to bipolar disorder and schizophrenia in previous studies and CACNB2).

Polygenic risk scores confirmed cross-disorder effects, most strongly between adult-onset disorders (bipolar and major depressive disorder, and schizophrenia). Further pathway analysis corroborated that calcium channel activity could play an important role in the development of all five disorders.

According to Smoller, “Significant progress has been made in understanding the genetic risk factors underlying psychiatric disorders. Our results provide new evidence that may inform a move beyond descriptive syndromes in psychiatry and towards classification based on underlying causes. These findings are particularly relevant in view of the imminent revision of classifications in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD).”

Writing in a linked Comment, Alessandro Serretti and Chiara Fabbri from the University of Bologna in Italy say, “the present study might contribute to future nosographic [classification] systems, which could be based not only on statistically determined clinical categories, but also on biological pathogenic factors that are pivotal to the identification of suitable treatments.”

They add, “genetics…can contribute to prediction and prevention of psychiatric diseases, along with the identification of molecular targets for new generations of psychotropic drugs.”

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Comments
  1. Jose Grecko Jose Grecko United States says:

    This will likely lead us to the final conclusion that the increases we see in the occurrence of ADHD, autism, bipolar and the like are caused by the heavy metals in the vaccines which we shot up our toddlers with by government order, which blocked the calcium pathways. Maybe its a combined effect, or maybe it is a chemical way to induce the same problems. Likely it will be proven and somebody will need an apology and about a trillion dollar settlement.

  2. WIlliam Higgins WIlliam Higgins United States says:

    I have been very excited about findings from the Walsh Research Institute about the same mental illnesses listed in this article being tied together by metals in the body being too much or too little.  Also over or under methylation. They have either healed or made better 75% of patients in research trials.  Evidently this is only one piece of the puzzle.  Maybe with this understanding about calcium and other discoveries they are making, the percentage of people they can help in the future will be closer to 100%.  THis is exciting.

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