Findings differ from previous study; UH Rainbow Babies and Children's Hospital researcher lead author
A new study from researchers at UH Rainbow Babies and Children's Hospital and other centers suggests that preterm infants with a low-grade bleeding in the brain may have similar neurodevelopmental outcomes as infants with no bleeding. The study appears online at JAMA Pediatrics.
The study's lead author Allison Payne, MD MS, a neonatologist at UH Rainbow Babies and Children's Hospital and instructor at Case Western Reserve University School of Medicine, said, "The results are important because it is a large multi-center study showing different results than a recent study that did find differences in outcomes at 2 years of age for babies with PIVH. Our study's results are similar to those reported by other international cohorts."
The bleeding is called periventricular-intraventricular hemorrhage (PIVH), a condition that can occur in preterm babies. Dr. Payne and her colleagues said that although the presence of severe PIVH strongly correlates with adverse motor and cognitive outcomes, "outcomes of survivors with low-grade PIVH (grade 1 or 2) are less fully understood despite accounting for 50 percent to 80 percent of all PIVH cases."
In this study, the researchers analyzed 1472 extremely preterm infants admitted to 16 pediatric medical centers, including UH Rainbow Babies and Children's Hospital, from 2006 to 2008 who survived to 18-22 months and had at least one cranial ultrasonography performed during their stay.