Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Published on May 7, 2013 at 9:41 AM · No Comments

Isis Pharmaceuticals, Inc. (NASDAQ: ISIS) announced the initiation of a Phase 1b/2a clinical study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma (HCC).  HCC is a tumor of the liver and is one of the most common cancers worldwide with at least one million new cases diagnosed each year.  ISIS-STAT3Rx is an antisense drug discovered by Isis and being developed to treat patients with cancers with a strong link to STAT3, such as HCC.  Isis licensed ISIS-STAT3Rx to AstraZeneca as part of a strategic alliance in cancer. AstraZeneca is conducting this newly initiated study in patients with HCC.

 "We are pleased to be working with AstraZeneca on the development of ISIS-STAT3Rx.  AstraZeneca's considerable resources, expertise and development capabilities to develop anti-cancer drugs strengthen substantially our ability to broadly evaluate ISIS-STAT3Rx across a range of cancer types. Given the role of STAT3 in the growth and survival of tumors, we believe that ISIS-STAT3Rx could be beneficial in the treatment of many different types of cancers.  As such, together with AstraZeneca, we have designed a broad development program to explore the effects of ISIS-STAT3Rx in a number of different cancers," said B. Lynne Parshall , chief operating officer at Isis.  "Our early work showed that ISIS-STAT3Rx treatment resulted in clear responses in patients with advanced cancer who were refractory to prior chemotherapy treatment, with an acceptable safety profile.  The new study builds on this early work and expands our evaluation of ISIS-STAT3Rx into liver cancer where STAT3 inhibition could also provide therapeutic benefit."

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