Results of post-mortem brain tissue study using Navidea's NAV4694 imaging agent presented at AAIC 2013

Published on July 23, 2013 at 12:43 AM · No Comments

Navidea Biopharmaceuticals, Inc. (NYSE MKT: NAVB), a biopharmaceutical company focused on precision diagnostic radiopharmaceuticals, today announced that researchers at McGill Center for Studies in Aging, Douglas Research Institute and Montreal Neurological Institute presented results of a post-mortem brain tissue study using Navidea's investigational Fluorine-18 labeled β-amyloid imaging agent, NAV4694, during the Alzheimer's Association International Conference (AAIC) in Boston, MA. The study comparing performance characteristics of NAV4694 to the gold-standard imaging agent, 11C-labeled Pittsburgh Compound-B (PiB), in control and AD brain tissue concluded that although the molecules share structural similarity, NAV4694 better differentiated amyloid deposition associated with AD in post-mortem brains than PiB.

“[18F]NAV4694 shows higher binding and wider dynamic range compared to [11C]PIB in Alzheimer's disease post-mortem tissue”

"Our research indicates that NAV4694 shows strong performance characteristics as an amyloid imaging agent for AD research and clinical use," said Pedro Rosa-Neto MD, PhD, Assistant Professor of Neurology, Neurosurgery and Psychiatry at McGill University, Quebec, Canada. "This study indicated that unlike PiB, the benchmark PET amyloid agent, NAV4694 was capable of differentiating controls from AD in all brain regions and also exhibited a wider dynamic range and fewer false negatives as compared to gold-standard pathology."

"We are very pleased that the McGill research team has shared these data with our colleagues and the scientific community at AAIC," said Connie Reininger, MD, PhD, Navidea's Senior Vice President and Chief Medical Officer. "We remain committed to providing physicians and patients an improved diagnostic agent that can aid in the differential diagnosis of Alzheimer's disease and other forms of neurodegenerative dementia. These results further support the recently announced AIBL decision to utilize NAV4694 in place of PiB in their comprehensive research initiative in AD and Mild Cognitive Impairment."

Source:

Navidea Biopharmaceuticals Inc.

Read in | English | Español | Français | Deutsch | Português | Italiano | 日本語 | 한국어 | 简体中文 | 繁體中文 | Nederlands | Русский | Svenska | Polski
Comments
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Findings provide insight into how brain represents innermost feelings