Jefferson Radiation Oncologist, Nicole Simone, M.D., was recently awarded one of 21 Young Investigator Awards from the Prostate Cancer Foundation (PCF).
The award, in the amount of $225,000, will be used to further her research in caloric restriction to decrease tumor growth and metastases in prostate cancer patients.
Young investigator awards support the most innovative minds in the field of prostate cancer research and are designed to promote long-term careers in prostate cancer research by providing three-year grants for transformational research focused on prostate cancer advances and new treatments to improve patient outcomes.
"This is an incredibly exciting area in cancer research today," says Adam Dicker, M.D., Ph.D., Chair of the Department of Radiation Oncology at Thomas Jefferson University and Hospital. "Dr. Simone's research connects nutrition, obesity and cancer; the opportunity to help patients through efforts that are under their control represents a fresh approach in the fight against cancer."
"We are particularly enthusiastic about this research because the PCF award will allow us to obtain the preclinical information needed so that we can use caloric restriction in clinical trials for our prostate cancer patients," says Dr. Simone.
Dr. Simone's research will use caloric restriction to decrease tumor growth and metastases in prostate cancer patients. Caloric restriction has proven successful in decreasing multiple molecules in the insulin like growth-factor (IGF) pathway in animal models, with a further decrease in this pathway noted when caloric restriction is combined with radiation or chemotherapy.