CHOP-led study of national records suggests need for screening, preventive measures following pediatric transplants
Children who undergo transplants of solid organs have a high risk of developing advanced kidney disease, according to a new national study. Among these children, the highest risk is in those receiving lung or intestinal transplants, followed by heart and then liver transplants. The researchers say their findings reinforce the importance of continued screening of kidney function in pediatric transplant recipients.
"We found that the risk patterns for kidney disease are different among patients who receive solid-organ transplants as children, compared to adult transplant recipients," said pediatric nephrologist Rebecca L. Ruebner, M.D., of The Children's Hospital of Philadelphia. "Because chronic and end-stage kidney disease carry high burdens of mortality and serious illness, it is important to take preventive measures to slow or prevent disease progression."
Ruebner is the first author of a study published online today in Pediatrics. The senior author is Susan L. Furth, M.D., Ph.D., chief of Nephrology at Children's Hospital.
Using data from the Scientific Registry of Transplant Recipients, the study team analyzed records of 16,600 pediatric patients who received solid-organ transplants (liver, heart, lung, intestine, and heart-lung) from 1990 to 2010 across the U.S. This was the first pediatric study to compare the relative incidence of end-stage kidney disease (ESKD) by type of organ transplant. It was also the first analysis to identify the risk of advanced kidney disease among pediatric solid-organ recipients over a 20-year period.