Development of Radiation Models of Cancer Will Enable the Discovery of More Effective Oncology Therapies
Crown Bioscience, Inc., a leading global drug discovery and development service company, today announces that it has entered into a collaboration with Xstrahl Ltd, a leading designer and manufacturer of X-Ray solutions for radiation biology research. As part of the agreement, CrownBio will be implementing the SARRP research platform supplied by Xstrahl, based on state-of-the-art Image Guided Micro-Irradiation (IGMI™) techniques at its PRECOS facility in Nottingham, UK. As a result of the partnership, CrownBio will be at the forefront of providing contract research oncology models that provide an irradiation service based on targeted beam radiation therapy, to more closely mimic the clinical situation for patients in the preclinical setting to help improve potential cancer treatment regimens.
CrownBio is the largest supplier of oncology services, with a global footprint spanning three major continents in North America, Europe and Asia Pacific. Via its collaboration with Xstrahl, the company is now able to offer its customers computerized tomography (CT) imaging with precise radiation delivery. High resolution imaging enables researchers to pinpoint an exact clinical target and deliver a precise radiation dose to in vivo and in vitro models. The platform provides the ability to perform combination studies in patient derived xenograft (PDX) and cell line derived xenograft (CDX) models as well as in vitro, in addition to irradiated subjects for haematological or more fastidious models.
Jean-Pierre Wery, President of CrownBio comments, “The partnership represents CrownBio’s commitment to providing its pharmaceutical and biopharmaceutical customers with specialized techniques and services. Radiation therapy is part of the treatment regimen for the majority of cancer patients worldwide. Therefore providing preclinical models which more closely reflect a patient’s condition should be a potential option for validating the efficacy of novel therapies and potential compounds that make tumor cells more sensitive to radiation therapy (radiosensitizers) for the treatment of cancer. The use of the IGMI technique in conjunction with our commercial models will provide a unique portfolio of models which more closely mimic the treatment regimen in the clinic, but in the preclinical setting.”