Innovative adhesive technology published as a cover feature in the high impact journal, Science Translational Medicine
Gecko Biomedical, a French medical device company developing 'bio-inspired' biodegradable surgical glues and patches for wound closure, announces that the Company's co-founders have published data demonstrating the potential of its paradigm-shifting technologies for minimally invasive reconstructive heart surgery.
'Bio-inspired' biodegradable surgical glue repairs defects of the heart and blood vessels
In a paper entitled "A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects", published in the January 8, 2014 issue of Science Translational Medicine (online) (Ref. 1), the authors, including Gecko Biomedical co-founders Robert Langer Sc.D. (Massachusetts Institute of Technology) and Jeffrey Karp Ph.D. (Brigham and Women's Hospital), describe a revolutionary biodegradable and biocompatible surgical glue that was inspired by adhesive mechanisms observed in nature that function in challenging yet comparable (wet and dynamic) environments to those found in the body.
The 'bio-inspired' glue described is non-toxic, binds strongly to tissues offering a leak-proof seal on demand, and works well in the presence of actively contracting tissues and blood flow. The authors demonstrate how the adhesive, alone or in conjunction with a biodegradable patch, can effectively be used to repair defects (ruptures) of the heart and blood vessels during minimally invasive procedures.
Precise control of the wound closure process could shift the surgical paradigm
The glue is based on the combination of safe, naturally occurring compounds to form a biocompatible pre-polymer with tunable adhesive and mechanical properties. The glue is soft and elastic when applied to the wet surfaces of the wounds where it adheres gently to the tissues, permitting fine adjustments or repositioning when used with the patch. The glue is activated (polymerized) upon exposure to ultraviolet (UV) light to form a strong, leak-proof but flexible seal, giving the surgeon full control of the process. The adhesive can be engineered with mechanical characteristics similar to arteries and the digestive system, where initial applications are targeted. The authors also describe how the composition of the pre-polymer can be adjusted for strength or rate of biodegradation to suit the wound being repaired.