TSRI researchers develop new fluid biopsy technique to identify patients at high risk of heart attack

Published on January 9, 2014 at 11:08 PM · No Comments

A new "fluid biopsy" technique that could identify patients at high risk of a heart attack by identifying specific cells as markers in the bloodstream has been developed by a group of researchers at The Scripps Research Institute (TSRI).

The technique, which is described in the latest edition of IOP Publishing's journal Physical Biology, works by identifying circulating endothelial cells (CECs) and has been successful in distinguishing patients undergoing treatment for a recent heart attack with a healthy control group.

The researchers believe the technique can now be tested on patients who exhibit symptoms but are yet to experience a heart attack. Currently, there is no predictive test for a heart attack-at least not of satisfying accuracy.

"The goal of this paper was to establish evidence that these circulating endothelial cells can be detected reliably in patients following a heart attack and do not exist in healthy controls-which we have achieved," said TSRI Associate Professor Peter Kuhn, who led the study. "Our results were so significant relative to the healthy controls that the obvious next step is to assess the usefulness of the test in identifying patients during the early stages of a heart attack."

Endothelial cells, which line the walls of the arteries, have been strongly linked to ongoing heart attacks when circulating in the bloodstream; they are thought to arrive there when diseased plaque builds up, ruptures and ulcerates, causing inflammation in the arteries. This damage can cause blood clots to form that prevent blood from flowing through the arteries and ultimately results in a heart attack.

As such, the researchers developed a procedure called the High-Definition Circulating Endothelial Cell (HD-CEC) assay to detect and characterise CECs in the blood samples of 79 patients who had experienced a heart attack at the time of sampling.

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