Everybody feels pain differently, and brain structure may hold the clue to these differences.
In a study published in the current online issue of the journal Pain, scientists at Wake Forest Baptist Medical Center have shown that the brain's structure is related to how intensely people perceive pain.
"We found that individual differences in the amount of grey matter in certain regions of the brain are related to how sensitive different people are to pain," said Robert Coghill, Ph.D., professor of neurobiology and anatomy at Wake Forest Baptist and senior author of the study.
The brain is made up of both grey and white matter. Grey matter processes information much like a computer, while white matter coordinates communications between the different regions of the brain.
The research team investigated the relationship between the amount of grey matter and individual differences in pain sensitivity in 116 healthy volunteers. Pain sensitivity was tested by having participants rate the intensity of their pain when a small spot of skin on their arm or leg was heated to 120 degrees Fahrenheit. After pain sensitivity testing, participants underwent MRI scans that recorded images of their brain structure.
"Subjects with higher pain intensity ratings had less grey matter in brain regions that contribute to internal thoughts and control of attention," said Nichole Emerson, B.S., a graduate student in the Coghill lab and first author of the study. These regions include the posterior cingulate cortex, precuneus and areas of the posterior parietal cortex, she said.