NIBIB-funded researchers develop microscopic technique to improve Mohs surgery

Published on January 29, 2014 at 7:51 AM · No Comments

The new imaging technique was tested on 17 patients with 34 tissue samples. The overall image quality was excellent, with high resolution and contrast, providing for good visibility of the epidermis and dermis. Researchers compared the new technique against the Mohs approach with its frozen section processing. The new technique achieved a promising 94% in preliminary measures of sensitivity and specificity for detecting skin cancer margins, which is comparable to the "gold standard" Mohs procedure. These preliminary results demonstrated that the optical technique could potentially detect skin cancer margins with the same accuracy as the conventional frozen section technique.

The results of this study were obtained under laboratory conditions; a clinical trial is now being conducted to demonstrate the feasibility of using this technique in the clinical setting, the ultimate goal of the research group.

Steve Krosnick, M.D., NIBIB director for the Program for Image-Guided Interventions, explains the utility of the optical system: "The technology is particularly well-suited for Mohs-trained surgeons, who are experts at performing excisions and interpreting images of tissue samples removed during the Mohs procedure. Image quality, ability to make accurate interpretations, and time savings will be key parameters for adoption of the system in the clinical setting, and the current results are very encouraging."

SOURCE National Institute of Biomedical Imaging and Bioengineering

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