Published on January 29, 2014 at 8:04 AM
"PDE10 is a novel target for the treatment of schizophrenia and other neuropsychiatric disorders with the potential to address limitations of current therapy," stated Michael Davidson, M.D., Professor in the Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel. "Inhibition of PDE10, which is a novel mechanism of action, may be able to treat not only the positive symptoms in schizophrenia but also the negative symptoms and cognitive impairment. The OMS824 data are the most promising of any PDE10 inhibitor, and I am eager to review additional clinical data for Omeros' drug product."
"We are excited by these positive clinical results," stated Gregory A. Demopulos, M.D., chairman and chief executive officer of Omeros. "Based on the favorable tolerability and pharmacokinetics of OMS824, we are considering evaluating additional higher dose levels in patients with schizophrenia. The data from the current trial open the door to developing OMS824 as monotherapy or in conjunction with other antipsychotics for schizophrenia and a wide range of other psychiatric and neurologic disorders."
In addition to its schizophrenia program, Omeros expects to begin enrollment this quarter in a Phase 2 clinical trial evaluating OMS824 in patients with Huntington's disease.
SOURCE Omeros Corporation