A single dose of intravenous glutamine (GLN) administered immediately after a non-lethal lower limb ischemia reduces the reperfusion inflammatory reaction locally and systemically according to a new study.
The study, published today in the OnlineFirst version of the Journal of Parenteral and Enteral Nutrition (JPEN), the research journal of the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), used a mice model to compare the effects of GLN on hind limb ischemia reperfusion (IR) injury.
The study subjected three groups of mice to 90 minutes of ischemia followed by a variable period of reperfusion. A fourth group was used as a control.
In summary, the study showed that GLN reduced the gene expressions of inflammatory mediator in muscle tissue and decreased blood macrophage percentage and plasma IL-6 concentrations at the early or late phase of reperfusion. Histological findings also found that remote lung injury was attenuated in IR injury. The results suggest that a single dose of GLN administration immediately after sub-lethal lower limb ischemia reduces the inflammatory reaction locally and systemically; this may offer local and distant organ protection in hind limb IR injury.
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