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A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe. The agent stimulates the body's immune system to recognize the agent as foreign, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.
TSRI scientists develop new strategy to design potential HIV vaccine candidates

TSRI scientists develop new strategy to design potential HIV vaccine candidates

Want to catch a criminal? Show a mugshot on the news. Want to stop HIV infections? Get the immune system to recognize and attack the virus's tell-tale structure. That's part of the basic approach behind efforts at The Scripps Research Institute to design an AIDS vaccine. [More]
Experts receive NIH grant to study why some HIV-infected individuals resist TB

Experts receive NIH grant to study why some HIV-infected individuals resist TB

Case Western Reserve University School of Medicine experts and colleagues in the United States and Africa have received an $11 million, five-year NIH grant to understand why some people living with HIV in Africa avoid becoming infected with the bacterium that causes tuberculosis (TB) despite exposure to high-TB-risk circumstances. [More]
Study: Zika virus infections last longer during pregnancy

Study: Zika virus infections last longer during pregnancy

University of Wisconsin-Madison researchers studying monkeys have shown that one infection with Zika virus protects against future infection, though pregnancy may drastically prolong the time the virus stays in the body. [More]
Study shows women with CIN3 more likely to develop anogenital cancers

Study shows women with CIN3 more likely to develop anogenital cancers

Women with a history of severe cervical intraepithelial neoplasia, a precancerous condition of the cervix that arises from infection with the human papillomavirus (HPV), had a long-term increased risk of developing anal, vulvar, and vaginal cancer. [More]
Two vaccine candidates provide complete protection against ZIKV infection in mice

Two vaccine candidates provide complete protection against ZIKV infection in mice

The rapid development of a safe and effective vaccine to prevent the Zika virus (ZIKV) is a global priority, as infection in pregnant women has been shown to lead to fetal microcephaly and other major birth defects. [More]
RepeatAnalyzer improves scientists' ability to identify, manage bacterial strains

RepeatAnalyzer improves scientists' ability to identify, manage bacterial strains

Washington State University researchers have developed a new software tool that will improve scientists' ability to identify and understand bacterial strains and accelerate vaccine development. [More]
Anthrax capsule vaccine offers protection from deadly anthrax infection in monkeys

Anthrax capsule vaccine offers protection from deadly anthrax infection in monkeys

Vaccination with the anthrax capsule--a naturally occurring component of the bacterium that causes the disease--completely protected monkeys from lethal anthrax infection, according to a study published online this week in the journal VACCINE. [More]
Strengthening immune defence system may provide treatment alternative for tuberculosis

Strengthening immune defence system may provide treatment alternative for tuberculosis

Researchers at Linköping University have made a discovery that could contribute to developing new vaccines and treatment alternatives for tuberculosis in the future. The results have been published in Scientific Reports, a sister journal to the highly respected periodical Nature. [More]
Scientists isolate antibodies capable of neutralizing dengue and Zika virus

Scientists isolate antibodies capable of neutralizing dengue and Zika virus

Scientists from the Institut Pasteur and the CNRS, in collaboration with Imperial College London and the University of Vienna, Austria, have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. [More]
SLU to conduct human clinical trial of vaccine to protect people from Zika virus

SLU to conduct human clinical trial of vaccine to protect people from Zika virus

Saint Louis University's vaccine center has been tapped by the National Institutes of Health to conduct a human clinical trial of a vaccine to prevent the Zika virus, which can cause devastating birth defects in babies. [More]
Pre-existing dengue antibodies can intensify Zika virus infection

Pre-existing dengue antibodies can intensify Zika virus infection

Previous exposure to the dengue virus may increase the potency of Zika infection, according to research from Imperial College London. [More]
MAIT cells of immune system can fight all sorts of bacterial and viral infections

MAIT cells of immune system can fight all sorts of bacterial and viral infections

Oxford University research has found that a little-studied and relatively unknown part of the human immune system could be twice as important as previously thought. [More]
Major review highlights lack of genetic understanding of Zika virus

Major review highlights lack of genetic understanding of Zika virus

A major review of the Zika virus has concluded that further research to understand the nature of the virus is critical to developing antiviral treatments and vaccines.The paper, published in the journal Veterinary Quarterly, considers the breadth of current research and highlights a lack of understanding of the nature of the virus. [More]
Inflammatory response to mosquito bites can help spread viral infections

Inflammatory response to mosquito bites can help spread viral infections

Mosquito bite sites are not just itchy, irritating nuisances - they also make viral infections spread by the insects far worse, new research has found. [More]
VUMC researchers aim to decode genetic underpinnings of human immune system

VUMC researchers aim to decode genetic underpinnings of human immune system

Researchers at Vanderbilt University Medical Center this month began recruiting volunteers to participate in a clinical trial aimed at decoding the human "immunome," the genetic underpinnings of the immune system. [More]
Unmanned drones could be economical to deliver vaccines quickly in developing countries

Unmanned drones could be economical to deliver vaccines quickly in developing countries

Using unmanned drones to deliver vaccines in low- and middle-income countries may save money and improve vaccination rates, new research led by the Johns Hopkins Bloomberg School of Public Health and the Pittsburgh Supercomputing Center suggests. [More]
Researchers aim to improve medical treatment for people with insect venom allergy

Researchers aim to improve medical treatment for people with insect venom allergy

A team of researchers has elucidated individual profiles of allergy reactivity in patients that are not protected after treatment with immunotherapy. The aim is to improve medical treatment of people who are allergic to insect stings. [More]
E-cigarette use modifies gene expression important for upper airway immune defense

E-cigarette use modifies gene expression important for upper airway immune defense

When we smoke cigarettes, dozens of genes important for immune defense are altered in the epithelial cells that line the respiratory tract. Several of these changes likely increase the risk of bacterial infections, viruses, and inflammation. [More]
Fractional dosing approach could be used to control yellow fever outbreaks during vaccine shortages

Fractional dosing approach could be used to control yellow fever outbreaks during vaccine shortages

The yellow fever vaccine given as one fifth of the regular dose could be used to control an outbreak in case of vaccine shortages. [More]
Revised Zika Strategic Response Plan focuses on preventing, managing medical complications

Revised Zika Strategic Response Plan focuses on preventing, managing medical complications

The World Health Organization (WHO)/the Pan American Health Organization (PAHO) and partners have set out their strategic response to Zika which will place a greater focus on preventing and managing medical complications caused by Zika virus infection. [More]
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