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A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe. The agent stimulates the body's immune system to recognize the agent as foreign, destroy it, and "remember" it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters.
Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

In a paper published today in Science Translational Medicine, researchers from Fred Hutchinson Cancer Research Center shared data from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy. [More]
Scientists discover potential new genetic causes for intellectual disability

Scientists discover potential new genetic causes for intellectual disability

An international group of researchers has for the first time identified a set of 30 inherited recessive genes that play a role in intellectual disability (ID), a neurodevelopmental disorder that, according to the Centers for Disease Control, affects as many as 213 million people around the world. [More]
Novel Trojan Horse antibody strategy may target Ebola's Achilles' heel

Novel Trojan Horse antibody strategy may target Ebola's Achilles' heel

In research published online today in Science, a team of scientists describe a new therapeutic strategy to target a hidden Achilles' heel shared by all known types of Ebola virus. [More]
Trial of high-dose flu vaccine aims to better protect heart failure patients

Trial of high-dose flu vaccine aims to better protect heart failure patients

A network of researchers in the United States and Canada will try to spare thousands of patients the dangers of heart attacks and hospitalizations over the next five years in a trial of a high-dose flu vaccine. [More]
Researchers reveal potential therapeutic treatment for alphavirus infections

Researchers reveal potential therapeutic treatment for alphavirus infections

Research conducted by Griffith University and Melbourne-based company Paradigm Biopharmaceuticals Limited has uncovered a potential new therapeutic treatment for the global battle against mosquito-borne alphavirus infections, including the debilitating Ross River Virus (RRV) and Chikungunya Virus (CHIKV). [More]
New vaccine against grass pollen allergies may help combat hepatitis B infection

New vaccine against grass pollen allergies may help combat hepatitis B infection

A new type of vaccine against grass pollen allergies (BM32) might also offer an effective treatment for combating hepatitis B infection. [More]
New collaborative initiative seeks to develop interventions for optimizing adult vaccination rates

New collaborative initiative seeks to develop interventions for optimizing adult vaccination rates

A new quality improvement initiative that aims to create effective solutions in optimizing adult vaccination rates was announced today. [More]
Study finds cord blood transplant recipients appear to have better outcomes against leukemia

Study finds cord blood transplant recipients appear to have better outcomes against leukemia

Umbilical cord blood transplants may have advantages beyond offering an alternative stem cell source for leukemia patients without a traditional donor match, according to a study published today in The New England Journal of Medicine. [More]
Changing dosing regimen could improve efficacy of malaria vaccine candidate, study shows

Changing dosing regimen could improve efficacy of malaria vaccine candidate, study shows

Researchers at the Walter Reed Army Institute of Research and collaborators recently published results of a phase II study which demonstrated that by changing the dosing regimen, the efficacy of malaria vaccine candidate, RTS,S/AS01, was improved to approximately 87%, compared with 63% using the current standard regimen. [More]
Researchers discover second line of defense in macaques co-infected with Mtb and SIV

Researchers discover second line of defense in macaques co-infected with Mtb and SIV

Tulane University researchers found some monkeys whose immune systems are depleted by the simian strain of HIV have a second line of defense against tuberculosis. [More]
Dengue vaccine may worsen infections if used in areas with low rates of disease

Dengue vaccine may worsen infections if used in areas with low rates of disease

The world's only licensed vaccine for dengue may worsen subsequent dengue infections if used in areas with low rates of dengue infection, suggests new research. [More]
Enzyme from oral bacteria could be potential therapy for celiac disease

Enzyme from oral bacteria could be potential therapy for celiac disease

Researchers have isolated an enzyme from bacteria present in human saliva that has potential as a therapy for celiac disease (CD), an autoimmune disorder that causes severe digestive and other health problems among sufferers when they consume gluten. [More]
New discovery offers way to develop vaccine against highly infectious bacteria

New discovery offers way to develop vaccine against highly infectious bacteria

Biochemists at the University of California San Diego have uncovered patterns in the outer protein coat of group A Streptococcus that could finally lead to a vaccine against this highly infectious bacteria--responsible for more than 500,000 deaths a year, including toxic shock syndrome and necrotizing fasciitis or "flesh-eating disease." [More]
Approved dengue vaccine may increase infection in certain settings, research suggests

Approved dengue vaccine may increase infection in certain settings, research suggests

The only approved vaccine for dengue may actually increase the incidence of dengue infections requiring hospitalization rather than preventing the disease if health officials aren't careful about where they vaccinate, new public health research published Sept. 2 in Science suggests. [More]
Mayo Clinic offers CDC’s Zika virus screening test

Mayo Clinic offers CDC’s Zika virus screening test

Mayo Clinic will offer the Zika virus antibody test developed by the Centers for Disease Control and Prevention. [More]
Official statistics may underestimate size of Zika epidemic, study suggests

Official statistics may underestimate size of Zika epidemic, study suggests

A study supported by FAPESP and coordinated by researchers at the São José do Rio Preto Medical School in São Paulo State, Brazil, suggests official statistics may underestimate the size of the epidemic caused by Zika virus. [More]
New collaborative initiative aims to improve adult immunization rates

New collaborative initiative aims to improve adult immunization rates

A new quality improvement initiative that aims to create effective solutions in optimizing adult vaccination rates was announced today. [More]
Cases of rotavirus infections fall by 84% thanks to vaccination

Cases of rotavirus infections fall by 84% thanks to vaccination

Figures published by Public Health England have shown that the number of diagnosed Rotavirus cases, a highly infectious virus which may cause vomiting and diarrhoea, have dropped by 84% since the introduction of a vaccine to the national childhood immunisation schedule in July 2013. [More]
Leading Chikungunya vaccine in clinical trial phase 2

Leading Chikungunya vaccine in clinical trial phase 2

With the first patient vaccinated, a Phase 2 clinical trial of a promising prophylactic vaccine candidate against Chikungunya fever has now commenced. The product is the most advanced Chikungunya vaccine candidate globally and is developed by the Austrian biotech company Themis Bioscience GmbH. [More]
MRI-guided focused ultrasound treatment improves quality of life in patients with essential tremor

MRI-guided focused ultrasound treatment improves quality of life in patients with essential tremor

Treatment with MRI-guided focused ultrasound significantly improves tremors and quality of life in patients with essential tremor (ET), the most common movement disorder, according to a study published in the August 25 issue of the New England Journal of Medicine. [More]
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