The cytokine IL-21 is primarily generated by CD4+ T cells and natural killer T (NKT) cells. T cell, B cell, natural killer (NK) cell, macrophage, and dendritic cell (DC) proliferation and differentiation need IL-21/IL-21 receptor (IL-21R) signaling.
The IL-21/IL-21R axis is important in viral infections, cancer, and a variety of immunological disorders, including inflammatory bowel disease (IBD), rheumatoid arthritis, and type 1 diabetes.
IL21 belongs to the γ chain cytokine family, which also includes IL2, IL4, IL7, IL9, and IL15. The JAK1 and JAK3 pathways are activated when IL21 binds to IL21R and the common chain (γc/CD132/IL2RG), which then activates the STATs (STAT1/STAT3/STAT5a/STAT5b), phosphoinositide 3-kinase (PI3K/Akt), and MAP kinase pathways.
IL2RA (CD25), IL2RB (CD122), IL4R (CD124), IL7R (CD127), and IL9R are all members of the γc family of cytokine receptors (CD129).
To aid in the research of this cytokine, Sino Biological has generated a panel of high-quality recombinant IL-21 and IL-21 receptor proteins.
Recombinant IL-21 cytokines and receptors
Sino Biological has created bioactive recombinant IL-21 cytokines from diverse species like human, mouse, rat, and canine sources.
Featured IL-21 protein
Human-IL-21 protein: 10584-HNAE
- HPLC-verified
- Tag-free
- High Activity
- High-purity
Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
>95% as determined by SEC-HPLC. Image Credit: Sino Biological Inc.
Batch-to-batch Consistency. Image Credit: Sino Biological Inc.
Other recombinant IL-21 Cytokines
Table 1. Source: Sino Biological Inc.
Cat# |
Species |
Tag |
Expressed Host |
Purity |
Activity |
50137-MNAE |
Mouse |
Native |
E. coli |
>97% |
Active |
70016-DNAE |
Canine |
Native |
E. coli |
>97% |
Active |
80200-R08B |
Rat |
C-His |
Insect Cells |
>90% |
Active |
80200-RNAE |
Rat |
Native |
E. coli |
>95% |
|
Featured IL-21R protein
Human IL-21R protein | 11483-H08H
Ability to inhibit IL-21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
Mouse IL-21R protein | 51184-M08H
Ability to inhibit mouse IL-21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
Other recombinant IL-21R protein
Table 2. Source: Sino Biological Inc.
Cat# |
Species |
Tag |
Expressed Host |
Purity |
Activity |
11483-H02H |
Human |
hFc |
HEK293 Cells |
>90% |
Active |
51184-M02H |
Mouse |
hFc |
HEK293 Cells |
>90% |
Active |
80189-R05H |
Rat |
mFc |
HEK293 Cells |
>90% |
|
80189-R08H |
Rat |
His |
HEK293 Cells |
>95% |
Active |
90315-C02H |
Cynomolgus, Rhesus |
hFc |
HEK293 Cells |
>90% |
Active |
90315-C08H |
Cynomolgus |
His |
HEK293 Cells |
>90% |
|
Other related proteins
- IL‐2
- IL-2RA (CD25)
- IL-2RB (CD122)
- IL-2RG (CD132)
- IL‐4
- IL-4R (CD124)
- IL‐7
- IL-7R (CD127)
- IL‐9
- IL-9R (CD129)
- IL‐15
Antibodies for IL-21 cytokines and receptors
Sino Biological has created a complete panel of antibodies that can be utilized in ELISA, WB, and IHC to target IL-21 cytokines and receptors.
Table 3. Source: Sino Biological Inc.
Antigen |
Cat# |
Species |
Clonality |
Application |
IL21 |
10584-MM01 |
Human |
Mouse MAb |
ELISA |
IL21 |
10584-R145 |
Human |
Rabbit MAb |
ELISA |
IL21 |
10584-T16 |
Human |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21 |
105972-T32 |
Rat |
Rabbit PAb, Antigen Affinity Purified |
WB |
IL21 |
50137-R012 |
Mouse |
Rabbit MAb |
ELISA |
IL21 |
50137-RP01 |
Mouse |
Rabbit PAb |
ELISA |
IL21 |
50137-T16 |
Mouse |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21 |
50137-T48 |
Mouse |
Rabbit PAb, Antigen Affinity Purified |
WB, ELISA |
IL21 |
70016-T16 |
Canine |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21 |
80200-R101 |
Rat |
Rabbit MAb |
ELISA |
IL21 |
80200-RP01 |
Rat |
Rabbit PAb |
ELISA |
IL21 |
80200-T16 |
Rat |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21R |
11483-MM06 |
Human |
Mouse MAb |
ELISA |
IL21R |
11483-R033 |
Human |
Rabbit MAb |
ELISA |
IL21R |
11483-RP01 |
Human |
Rabbit PAb |
ELISA |
IL21R |
11483-RP02 |
Human |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21R |
11483-T24 |
Human |
Rabbit PAb, Antigen Affinity Purified |
ELISA, IHC-P |
IL21R |
51184-RP01 |
Mouse |
Rabbit PAb |
ELISA |
IL21R |
51184-T16 |
Mouse |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21R |
80189-T16 |
Rat |
Rabbit PAb, Antigen Affinity Purified |
ELISA |
IL21R |
90315-RP01 |
Cynomolgus |
Rabbit PAb |
ELISA |
IL21R |
90315-T16 |
Cynomolgus |
Rabbit PAb, Antigen Affinity Purified |
ELISA |