Alginate methacrylate-based TissueFab® bioink (GelAlgHa)ma-UV/365 nm is used in 3D bioprinting applications. The formulation can be utilized to bioprint cell-laden hydrogels in the required shape without any supporting material and is suited for 3D bioprinting of tissues and structures utilizing extrusion-based 3D bioprinters.
UV light can crosslink printed structures in a single step, allowing for additional cell culture and maturation for tissue engineering and regenerative medicine applications.
Hyaluronic acid, alginate, and gelatin are the three natural polymers from this bioink. An anionic, nonsulfated glycosaminoglycan (GAG) hyaluronic acid is also known as sodium hyaluronate or hyaluronan. Alginate is often called sodium alginate or alginic acid, a natural biopolymer derived from brown algae.
A typical natural polysaccharide utilized in tissue engineering is alginate. Gelatin includes bioactive peptide sequences similar to those in the native extracellular matrix, which encourages integrin-mediated cell adhesion and MMP-sensitive enzymatic breakdown, which are necessary for cellular activities, including migration, proliferation, and differentiation.
Features and benefits
- High printing fidelity and cell viability ready-to-use formulation that bypasses the time-consuming bioink formulation development procedure
- MilliporeSigma 3D Bioprinting Scientists designed and tested step-by-step techniques; no prior 3D bioprinting experience is required
- Appropriate for various extrusion-based 3D bioprinter models
Image Credit: Merck
Properties
Source: Merck
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| Quality Level |
100 |
| Description |
Suitable for 3D bioprinting applications |
| Sterility |
Sterile-filtered |
| Form |
Viscous liquid (or gel) |
| Impurities |
≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden (Total Aerobic) |
| Color |
Colorless to pale yellow |
| Particle size |
0.2 μm |
| pH |
6.5-7.5 |
| Application(s) |
3D bioprinting |
| Storage temp. |
2-8 °C |
Packaging
10 mL in a glass bottle