Physician scientists at the Texas Heart Institute at St. Luke's Episcopal Hospital (THI at St. Luke's) have been awarded a grant of almost $1.5 million by the National Institutes of Health for research into treatments for patients with end-stage heart failure that would combine heart-assist devices and adult stem-cell treatments.
“We are excited about the potential for combining stem cells with LVADs, two powerful therapies in the treatment of patients with end-stage heart failure”
THI has been a pioneer in both areas of treatment, and a successful result could lead to even more effective treatments for thousands of patients with heart failure who have no other options.
"We are optimistic that resting the heart with the LVAD [heart-assist device] after cell therapy will lead to improved cardiac function and patient survival," said Dr. Igor Gregoric, Director of the THI at St. Luke's Center for Cardiac Support and one of the principal investigators in the research.
THI at St. Luke's is recognized as a leader in using adult stem-cells as an applied therapy for heart failure. THI doctors were the first in the world to successfully treat patients with coronary heart disease and severe heart failure using patients' own bone marrow-derived adult stem cells injected directly into their damaged hearts to improve function. THI was also the first facility in the United States with an FDA-approved protocol to study the use of adult stem cells in the treatment of patients and remains one of only five institutions nationwide selected by the National Institutes of Health to be part of a new Cardiovascular Cell Therapy Research Network.
THI has also been instrumental in the development and refinement of heart-assist devices (LVADs), which have been approved as bridges to transplant for patients awaiting heart transplants, and as "destination therapy" for permanent use in patients not eligible for transplants. In some patients, LVAD therapy has enabled damaged hearts to recover blood flow and heart function, obviating the need for a transplant.
Physician scientists hope the new research will lead to improvements in both areas of treatment. Also among the goals of the research will be to clarify which therapy or combinations of therapy will best enhance new blood flow and improved function in damaged areas of the heart. Scientists also expect to design the protocols for eventual human trials.