NewYork-Presbyterian Hospital/Columbia University Medical Center has established a new center devoted to research and treatment of pre-leukemia blood disorders. Known as the Myelodysplastic Syndromes Center, it is one of the largest programs of its kind in the nation.
Myelodysplastic syndromes (MDS) are disorders interfering with blood production in the bone marrow. Approximately one-third of patients with MDS progress to acute myelogenous leukemia -- a cancer characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
The new MDS Center is led by Dr. Azra Raza, who is also professor of medicine at Columbia University College of Physicians and Surgeons. A world authority on MDS, Dr. Raza has been advancing new treatments for myeloid disorders since the 1980s. Her research into the biology of MDS led to the approval of new treatments, notably lenalidomide.
Dr. Raza continues to pursue research on a number of fronts. The Center is testing the effects of novel drugs and is now developing treatments for early-stage MDS.
"Traditionally, even if we were able to catch MDS early, we were unable to treat it. Because the current therapies are very potent with multiple side effects, we have to tell patients to wait on treatment until their disease progresses. To address this issue, we are working to develop new treatments for early-stage MDS using nontoxic, natural substances," says Dr. Raza. "Preliminary research has shown that ginger, curcumin and coenzyme Q10 have been effective treatments for some patients. Going forward we are looking at a more powerful form of ginger that looks promising in pre-clinical studies."