Women who have gene mutations that put them at high risk of ovarian and breast cancer can significantly reduce the risk of developing or dying from these cancers by having their healthy ovaries or breasts removed, according to a new study reported in the Sept. 1 issue of the Journal of the American Medical Association.
Creighton University's Hereditary Cancer Center was one of 22 clinical and research genetics centers in Europe and North America to be involved in the study of 2,482 women with inherited BRCA1 or BRCA2 gene mutations between 1974 and 2009.
Henry Lynch, M.D., director of the Hereditary Cancer Center and holder of the Charles F. and Mary C. Heider Endowed Chair in Cancer Research at Creighton, is one of the study's co-authors.
"These findings should help women with these mutations and their doctors select strategies to reduce a patient's chances of developing breast and gynecological cancers," Lynch said. "The bottom line is that lives can be saved. Clearly, these are compelling results, demonstrating that preventive surgery offers a significant level of protection against breast and ovarian cancer for women carrying the BRCA1 and BRCA2 gene mutations."
The study followed each of the women for about four years. During the study, women who had their ovaries and fallopian tubes removed (a procedure known as salpingo-oophorectomy) reduced their risk of dying from ovarian cancer by 79 percent and from breast cancer by 56 percent.
Other findings:
• None of the women who underwent preventive mastectomies developed breast cancer, however 7 percent of the women who declined surgery did.
• Only 1 percent of the women who had at least one ovary and fallopian tube removed developed ovarian cancer, compared to 6 percent of the women who declined this surgery.
• Salpingo-oophorectomy also reduced the chances of getting breast cancer; 11 percent of the women undergoing this surgery developed breast cancer, compared to 19 percent who did not have surgery.