During depression, the brain becomes less plastic and adaptable, and thus less able to perform certain tasks, like storing memories. Researchers at the Swedish medical university Karolinska Institutet have now traced the brain's lower plasticity to reduced functionality in its support cells, and believe that learning more about these cells can pave the way for radical new therapies for depression. "We were able to cure memory dysfunction in 'depressed' rats by giving them doses of D-serine," says Mia Lindskog, biologist and Assistant Professor at Karolinska Institutet's Department of Neuroscience.
Dr Lindskog and her team used FSL rats, which are rats that have been specially bred with a disposition for 'depression'. The rats were first put through two tests to confirm that they had the symptoms that are also characteristic of human depression. In the first, the rats' memories were checked by repeatedly being exposed to different objects; in the second, the team assessed their level of apathy by releasing them in a container of water and observing whether they merely stayed floating in the container or immediately tried to climb out (non of the rats had to stay in the water for more than five minutes). In both cases the FSL rats' results were compared with normal laboratory rats, and memory disorders and apathy could be confirmed.
The researchers then injected the rats with D-serine. This substance improved their memories but had no effect on the apathy. "We have shown that there are two symptoms here that can be influenced independently of one another, which means they could be treated in tandem in patients with depression," says Dr Lindskog. The researchers also studied the synaptic activity in the hippocampus of the rats, a part of the brain which plays an important part in the memory.