N-of-One develops unique knowledge integration platform for oncologists

N-of-One, Inc., provider of Diagnostic Strategy Roadmaps™ and Treatment Strategy Roadmaps™ for personalized cancer care, announced today that the company has developed a unique knowledge integration platform to enable care providers and patients to make informed decisions about diagnostic and treatment strategy. The platform, called PrecisionWorks™, is designed to empower physicians to deliver personalized care for every cancer patient.    

"We're living in a time of unprecedented opportunity to transform cancer treatment and outcomes, driven by rapid advances in our understanding of molecular biology, genomics, and related technologies," said Jennifer Levin Carter, MD, MPH, Founder, President, and Chief Medical Officer of N-Of-One. "Now that we have the knowledge and technologies required to more precisely tailor treatment by targeting molecular drivers of each patient's disease, the real challenge has been in putting the relevant capabilities effectively into clinical practice."

PrecisionWorks powers clinically actionable deliverables that help medical teams make the most informed decisions possible when individualizing diagnostic and treatment strategy. N-of-One's solutions, created by the company's team of oncologists and scientists, include:

• Diagnostic Strategy Roadmaps identify key relevant biomarkers to be evaluated in each patient's specific tumor type, based on the latest molecular oncology research and on targeted treatments available for those biomarker alterations. N-of-One coordinates testing at top CLIA-approved diagnostic laboratories.
• Treatment Strategy Roadmaps link positive biomarkers identified in the patient's tumor to targeted therapies that may be effective against the patient's specific cancer, all within the context of the individual's other known molecular alterations and relevant disease history.
• MarkerMatch™ matches patients with current clinical trials that are relevant to their particular cancer type and molecular profile.

N-of-One has evolved PrecisionWorks since the company's launch in 2008 to integrate and streamline the fast-moving, data-intensive realm of cancer research, diagnostics, and treatment. While the company's early focus has been on the direct-to-consumer needs of individual cancer patients, PrecisionWorks provides a new level of functionality designed to meet the needs of physicians and healthcare providers to access the very latest knowledge and technologies they need, when they need them, to individualize diagnostic and treatment decisions for each patient.

"We've always believed in tackling the complexity of the personalized oncology system from the perspective of the individual patient, and initially, we worked directly with patients to deliver our knowledge platform and solutions for accessing personalized care," said Dr. Carter. "Over time, we have evolved and optimized PrecisionWorks from a direct-to-patient approach into an integrated, systematized platform that enables us now to expand access to much larger groups of patients through oncologists, regional cancer centers, provider networks, and diagnostic laboratories, while still providing our direct-to-patient solutions. In addition to delivering PrecisionWorks to providers at the point of care, N-of-One is implementing a partnering strategy with diagnostic companies that draws on selective components of the PrecisionWorks platform to transform the molecular alteration data from their tests into customized, clinically relevant reports that help clinicians better understand and act upon the test results."

The PrecisionWorks platform integrates:

• MarkerMine™, a comprehensive molecular knowledge database that brings together two types of data not previously integrated in healthcare management: Individual patient data, and the latest molecular knowledge about cancer
• Advanced analytic capabilities for synthesizing and transforming different types of information (including molecular, genomic, patient, therapeutic, diagnostic, population, etc.) into patient-specific knowledge that drives a targeted-care approach
• Logistics management systems to address the unique logistical and procedural challenges of delivering personalized cancer care by simplifying coordination among health care providers, diagnostic companies, payers, drug companies, and patients

"Healthcare providers need these capabilities now to provide their patients access to the same leading-edge, data-driven knowledge and decision-support tools as the field's top experts," said Christine Cournoyer, Chief Executive Officer of N-of-One. "What we're providing today are services and solutions that allow providers to more rapidly and cost effectively deploy the knowledge and resources they need to improve patient outcomes through precision oncology."