Sunflower peptides can treat itchy skin problems

Published on June 26, 2012 at 2:54 AM · No Comments

Sunflowers may hold the solution to a problem which gets under the skin of millions of Australians every year.

Skin conditions such as eczema, dermatitis, rosacea and the lesser-known Netherton Syndrome pose an itchy problem for many sufferers world-wide, but a group of researchers from Queensland University of Technology (QUT), in Brisbane Australia, are looking at ways to soothe the problem - with tiny proteins called peptides, found in sunflowers.

Simon de Veer, a PhD student and researcher for QUT's Institute of Health and Biomedical Innovation (IHBI) said his team was working to develop novel inhibitors for three skin proteases - enzymes which play an important role in the skin's constant regeneration.

By engineering the peptide known as sunflower trypsin inhibitor (SFTI), and modifying its binding surface, researchers have designed inhibitors for three skin proteases, kallikrein-related peptidase (KLK) 5, 7 and 14.

Mr de Veer said it is these inhibitors that are the missing piece of the puzzle for sufferers of skin conditions.

"Proteases in the skin are primarily involved with shedding old cells from the skin's surface by breaking the connections which normally hold them together as part of a protective barrier," he said.

"This requires a balancing mechanism to maintain regular skin structure and thickness.

"Too much activity leaves the skin more permeable than usual, meaning it is open to allergens, infection and water loss."

The naturally occurring SFTI peptide is an effective inhibitor of a protease called trypsin, which resembles the kallikrein proteases in our skin.

"Our goal was to harness the built-in activity of SFTI and give the binding surface a bit of a facelift so it was better able to target skin proteases and help restore the skin to its original state."

Read in | English | Español | Français | Deutsch | Português | Italiano | 日本語 | 한국어 | 简体中文 | 繁體中文 | Nederlands | Русский | Svenska | Polski
Comments
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post