Researchers from IMIM (Hospital del Mar Medical Research Institute) have deciphered the function executed by a protein called β-catenin in generating blood tissue stem cells. These cells, also called haematopoietic, are used as a source for transplants that form part of the therapies to fight different types of leukaemia. The results obtained will open the doors to produce these stem cells in the laboratory and, thus, improve the quality and quantity of these surgical procedures. This will let patients with no compatible donors be able to benefit from this discovery in the future.
The study, executed jointly with the Erasmus Medical Center Stem Cell of Rotterdam and published in the Journal of Experimental Medicine, analysed a chain of molecular reactions that are produced inside some embryonic cells and that play a role in the creation of a haematopoietic stem cells. 'Our study contributes to deciphering the code that makes a precursor cell that is only found in the embryo become a haematopoietic stem cell. In order for that to happen, the β-catenin protein must be activated for a while and with a specific dosage' explains Dr Anna Bigas, head of the IMIM Stem Cells & Cancer Group and lead researcher.
This protein also plays a fundamental role in the cells that originate and maintain some types of leukaemia. 'The parallelisms between normal and leukaemia stem cells prove to us that the molecular pathways that regulate both populations are the same. For this reason, our work will help us understand the origin of these diseases', argues Dr Bigas.