A direct, head-to-head comparison of two of the newer treatments available for type 2 diabetes yielded mixed results.
The 26-week, multicenter DURATION-6 clinical trial found that daily injections of liraglutide (Victoza) were slightly more effective than weekly injections of exenatide (Bydureon) in lowering blood sugar and promoting weight loss in patients with type 2 diabetes. However, the patients taking exenatide suffered fewer negative side effects such as nausea, diarrhea and vomiting.
"Both of these agents are very exciting diabetes products and really good blood sugar-lowering drugs," said John B. Buse, MD, PhD, first author of the study, division chief of endocrinology and metabolism in the University of North Carolina School of Medicine, director of the UNC Diabetes Care Center and a a PI Extender of the UNC NIH Clinical and Translational Science Awards (CTSA).
"The results of this study will be helpful to both doctors and patients in shared decision-making about which of these two drugs is better suited for a particular patient."
"The results of this study will be helpful to both doctors and patients in shared decision-making about which of these two drugs is better suited for a particular patient," Buse said. "For example, for some patients the additional weight loss advantage provided by liraglutide might tip the scales in favor of that drug. For other patients, though, the greater convenience of once-weekly injections and the more favorable side effects profile of exenatide would be extremely appealing."
Results of the study were published online ahead of print on Nov. 7, 2012 by The Lancet.