Stapled Peptide oncology drug candidate exhibits robust efficacy in xenograft cancer models

Published on November 8, 2012 at 5:08 AM · No Comments

Aileron Therapeutics, Inc. and its collaborator Roche today announced new results of a preclinical study of its Stapled Peptide oncology drug candidate ATSP-7041, which exhibited robust efficacy in MDM2 and MDMX xenograft cancer models. The study represents an important step towards establishing ATSP-7041 as the first highly potent and specific dual inhibitor of MDM2 and MDMX for p53-dependent cancers. ATSP-7041 was developed as part of Aileron's collaboration with Roche to discover, develop and commercialize Staple Peptide drugs. The data were presented today at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (abstract number 226).

“We are particularly excited to see the emergence of this important program as we prepare to enter the clinic with our first Stapled Peptide drug for endocrine disorders early next year.”

Stapled Peptides are a new class of drugs, one of the first in 20 years, with the potential to attack complex diseases, including cancer, endocrine/metabolic disorders and inflammation. ATSP-7041 is a novel, selective Stapled Peptide dual inhibitor of MDM2 and MDMX, crucial regulators for the p53 pathway. The well-studied p53 pathway has long been pursued by the pharmaceutical industry as it represents a first line of defense and one of the most important tumor suppressor proteins in virtually all cancer types. Inhibition of MDM2 and MDMX leads to reactivation of the p53 pathway, thereby driving tumor cells to apoptotic death.

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