Mistletoe has become an important symbol of Christmas but it also has the potential to play a vital role as an alternative therapy for sufferers of colon cancer.
At the University of Adelaide in Australia, scientists are interested in how the extract of mistletoe could either assist chemotherapy or act as an alternative to chemotherapy as a treatment for colon cancer.
Colon cancer is the second greatest cause of cancer death in the Western world. Mistletoe extract is already authorized for use by sufferers of colon cancer in Europe, but not in some countries such as Australia and the United States due to a lack of scientific testing.
For her Honours research project recently completed at the University of Adelaide, Health Sciences student Zahra Lotfollahi compared the effectiveness of three different types of mistletoe extract and chemotherapy on colon cancer cells. She also compared the impact of mistletoe extract and chemotherapy on healthy intestinal cells.
In her laboratory studies, she found that one of the mistletoe extracts - from a species known as Fraxini (which grows on ash trees) - was highly effective against colon cancer cells in cell culture and was gentler on healthy intestinal cells compared with chemotherapy.
Significantly, Fraxini extract was found to be more potent against cancer cells than the chemotherapy drug.
"This is an important result because we know that chemotherapy is effective at killing healthy cells as well as cancer cells. This can result in severe side effects for the patient, such as oral mucositis (ulcers in the mouth) and hair loss," Ms Lotfollahi says.
"Our laboratory studies have shown Fraxini mistletoe extract by itself to be highly effective at reducing the viability of colon cancer cells. At certain concentrations, Fraxini also increased the potency of chemotherapy against the cancer cells.