Drugs that bind to specific serotonin receptors can improve and impair female sexual function

Published on December 12, 2012 at 12:07 PM · No Comments

The drug with the positive impact, called Flibanserin, was developed as a potential non-hormonal treatment for pre-menopausal women with hypoactive sexual desire disorder (HSDD). HSDD is the most commonly reported female sexual complaint and is characterised by a persistent lack of sexual fantasies or desire that causes marked personal distress and/or personal difficulties. Aubert suggests that Flibanserin's therapeutic effects in women with HSDD may stem from improvements in sexual, social and emotional bonding between partners.

Unraveling the neurobiology of female sexual behaviour

Using a monkey model provided the researchers with the opportunity to ask detailed questions about the neurobiological underpinnings of female sexual behaviour. Aubert and his teams of researchers in Madison (Wisconsin, U.S.A.) and in Leiden conducted endocrine, imaging and genetic experiments to learn about hormonal and brain activity and gene expression patterns that are involved in the processes leading to impaired or improved female sexual and social behaviour. 'I believe that our results provide new leads and may spur renewed interest in the study of female sexual function - a topic that has been a taboo, or marginalised, for too long,' comments Aubert. 'Our study suggests that oxytocin may be the pivot of serotonergic regulation of female sexual behaviour, pair-bond and pharmacotherapy of HSDD; a finding that warrants attention in future studies.'

Source: http://www.news.leiden.edu/news-2012/dissertation-aubert.html

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