Liver transplants worth risk for people who have genetic liver conditions, study finds

Published on April 6, 2013 at 8:20 AM · No Comments

Journal of American College of Surgeons study reports that, despite the risks and the costs, liver transplant may also serve as a model for gene therapy through solid organ transplantation for some patients

Patients faced with the diagnosis of a life-threatening liver disease have to consider the seriousness of having a liver transplant, which can be a definitive cure for many acquired and genetic liver diseases. Among the main considerations are the anxiety of waiting for a donor organ, the risks associated with the transplant operation, and the chance that the transplant procedure will not achieve the desired result. There is also the six-figure cost of the procedure and accompanying patient care, all of which may not be completely covered by health insurance. But, according to a study appearing in the April issue of the Journal of the American College of Surgeons, researchers at the David Geffen School of Medicine, University of California-Los Angeles (UCLA), found that liver transplants are worth the risk for people who have genetic liver conditions.

The study is a first-of-its-kind, single-institution comparison of outcomes for both pediatric and adult patients undergoing liver transplantation for lethal genetic syndromes. Researchers found that children with genetic disorders that cause fibrosis, cirrhosis, and other liver conditions, which can affect other organs, have a good chance of still being alive five years, even 20 years after a liver transplant operation. Adults with these types of conditions also have high survival rates.

"If we had not transplanted these patients, long term, they would have died," said study lead author, Henrik Petrowsky, MD, who was an attending transplant surgeon and assistant professor of surgery at UCLA during the time the study was conducted.

Patients with genetic liver conditions are different from those who developed liver diseases from a hepatitis C infection or alcoholism. First, this patient population is less common. Dr. Petrowsky estimates that only about nine percent of liver transplants in children and only two percent in adults are performed as a treatment to correct genetic conditions. Second, the severity of genetic liver disease may not be as obvious. Since donated livers are allocated according to who needs them most, people with genetic liver diseases often have to be given extra consideration when weighing how long they can wait for a donor organ.

Although the genetic defect permeates every cell in the affected patient's body, it expresses mainly in the liver. However, certain disorders could also affect other organs. During a transplant, when the old liver is replaced with a new one "it's almost a form of gene therapy," explains Dr. Petrowsky, who is now vice chair of the department of visceral and transplant surgery at the University Hospital Zurich in Switzerland. "The genetic defect is still in every cell, but since it's mainly expressed in the liver, the genetic disorder is corrected by the transplanted liver which does not harbor the genetic defect."

Dr. Petrowsky's team wanted to evaluate the impact of the transplant procedure on patients' outcomes, especially because patients families go through so much before a transplantable liver can be procured. Therefore, the investigators looked at patient records from the UCLA liver transplant database for 74 children and 78 adults who had received liver transplants between 1984 and 2012 to correct genetic disorders. For 68 percent of those patients, the genetic disorder led to cirrhosis, or scaring of the liver, making liver transplantation their only hope for survival.

Five years later, 89 percent of children in the study were still alive, and 77 percent were still alive 20 years later. For adults, 73 percent were still alive after five years and 50 percent were still alive after 20 years.

"Without a transplant, the five-year survival rates are below five percent, depending on the severity of the liver disease," Dr. Petrowsky said.

Read in | English | Español | Français | Deutsch | Português | Italiano | 日本語 | 한국어 | 简体中文 | 繁體中文 | Nederlands | Русский | Svenska | Polski
Comments
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post