Scientists at the University of East Anglia have made a major advancement in understanding tissue development that has important implications for cancer.
Findings published today in the Journal of Cell Science show how the protein EB2 is a key regulator of tube-like structures inside cells and critical for normal tissue development and function.
The findings are an important step in the race to find cures for cancers including gut, breast and pancreatic cancer.
Microtubules are tubular structures that make up the internal 'skeleton' of cells and perform many essential functions. EB2 belongs to an important group of proteins that influence the behaviour of microtubules.
Researchers investigated the microtubule make-up of cells in epithelium tissue, which is one of the four basic types of animal tissue along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the cavities and surfaces of structures throughout the body and also form many glands.
Lead researcher Dr Mette Mogensen, from UEA's school of Biological Sciences, said: "We found that EB2 is a key regulator of microtubule reorganisation which is essential for normal epithelial development and function.
"Our findings represent a major advancement in our understanding of how these cell structures work and change, which not only has implications for the maintenance of a healthy tissue but also for cancer.