Novel First-in-Class Peptide Inhibitor of TREM-1 Modulates the Inflammatory Response and Shows Promise for Treatment of Cancer and Sepsis
SignaBlok, Inc., a Massachusetts-based biopharmaceutical company, today announced the successful in vivo proof of concept data that demonstrate that the company's novel mechanism-based, first-in-class peptide inhibitor of TREM-1 effectively suppresses cancer progression in mouse models of lung cancer and dramatically improves survival in septic mice.
SignaBlok’s innovative approach to cancer and sepsis targets a specific receptor called TREM-1 that is expressed on inflammatory cells, macrophages, and serves as an inflammation amplifier. This receptor is critically involved in cancer, sepsis and other inflammation-related diseases. The approach includes the use of short synthetic peptides that employ novel, ligand-independent mechanisms of TREM-1 inhibition and are designed using a new model of cell signaling, known as the SCHOOL model.
The data were first unveiled at the 2013 American Association of Immunologists Annual Meeting in Honolulu, HI, in talk and poster entitled "A novel ligand-independent peptide inhibitor of TREM-1 modulates the inflammatory response and improves survival in septic mice (P4210)" and at the 2013 Gordon Research Conference on Cancer Nanotechnology in West Dover, VT, in poster entitled "Nature-inspired nanotheranostics for targeted cancer imaging and therapy".