New research illuminates definitive brain alterations in troops with Gulf War Illness (GWI) thought to result from the exposure to neurotoxic chemicals, including sarin gas, during the first Persian Gulf War.
"More than 250,000 troops, or approximately 25% of those deployed during the first Persian Gulf War, have been diagnosed with Gulf War Illness (GWI). Although medical professionals have recognized the chronic and often disabling illness for almost two decades, brain changes that uniquely identify GWI have been elusive until now," explained principal investigator Bart Rypma of The University of Texas at Dallas.
This study, published in Clinical Psychological Science, a journal of the Association for Psychological Science, is novel in that it confirms GWI deficits in working memory, a critical cognitive function that enables short-term retention of information for higher-level thinking ability.
In addition, brain alterations revealed in the study show a consistent pattern representing a neurobiological marker that could potentially be used to positively identify GWI.
The research team assessed three aspects of working memory: accuracy, speed, and efficiency. Results showed that participants with GWI performed significantly slower and less accurately than matched healthy veterans, and their efficiency decreased with increasing task difficulty.
During these difficult conditions, the participants showed relatively lower levels of activity in prefrontal brain regions which may compromise their ability to implement effective, higher-level thinking strategies in cognitively demanding situations.
"Our results revealed that at the root of cognitive issues in GWI patients are profound working memory deficits that correlate with a unique brain change visible in the fMRI scanner. These results support an empirical link between exposure to neurotoxic chemicals, specifically sarin nerve gas, and cognitive deficits and neurobiological changes in the brain," said Rypma. "Implementing interventions that improve working memory could have positive effects on many aspects of daily life from the ability to complete a shopping list, match names with faces, all the way to elevating mood."