MRI-Guided Stereotactic Laser Ablation (SLA) of the hippocampus to control seizures in people with temporal lobe epilepsy (TLE) may result in seizure control that approaches that from anterior temporal lobectory or selective amygdalohippocampectomy and better cognitive outcomes than any of the standard open resections, according to a study presented at the American Epilepsy Society's 67th Annual Meeting in Washington DC. If the SLA continues to prove safe and shows adequate efficacy for seizure control, the technique has the potential to drastically change brain surgery.
Stereotactic laser ablation is a brain surgery technique that preserves more brain regions and interconnections. Traditional surgery, such as amygdalohippocampectomy, typically requires a fairly large resection that cuts through other temporal lobe regions and white matter pathways. This resection approach results in cognitive morbidity involving potential deficits in material-specific memory and visual confrontational naming. (abstract and platform session B.07)
Using pre- and post-surgical neuropsychological data at 6-months following surgery, the research compared the cognitive outcomes for 10 people with TLE who had standard surgical treatment with the cognitive outcomes of 7 patients who underwent SLA for TLE. The study found that the cognitive declines were less following laser ablation than standard approaches. In addition to the cognitive benefits, the SLA technique is minimally invasive and is therefore more cosmetically appealing and involves less discomfort. It also decreases the length of hospital stay.