Published on December 17, 2013 at 11:43 PM
"Reversing the maturation process prevents the intensification process of cocaine craving," said Dong, the study's corresponding author and assistant professor of neuroscience in Pitt's Kenneth P. Dietrich School of Arts and Sciences. "We are now developing strategies to maintain the 'reversal' effects. Our goal is to develop biological and pharmacological strategies to produce long-lasting de-maturation of cocaine-generated silent synapses."
Dong collaborated with Susan Sesack, Pitt professor of neuroscience; Oliver Schl-ter, independent group leader at the European Neuroscience Institute; Yavin Shaham, senior investigator for the Intramural Research Program of the National Institute on Drug Abuse; Eric Nestler, Nash Family Professor of Neuroscience and director of the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai; and Marina Wolf, professor and chair of the Department of Neuroscience at the Chicago Medical School, Rosalind Franklin University of Medicine and Science.
Source: University of Pittsburgh